PFK-158 |CAS:1462249-75-7 Probechem Biochemicals

Chemical Structure : PFK-158

CAS No.: 1462249-75-7

PFK-158 (PFK 158;PFK158)

Catalog No.: PC-42914Not For Human Use, Lab Use Only.

PFK-158 is the first potent, selective and competitive small molecule inhibitor of PFKFB3 with IC50 of 137 nM, inhibits glycolysis, induces apoptosis and autophagy.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$248	In stock
100 mg	$398	In stock
200 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

PFK-158 is the first potent, selective and competitive small molecule inhibitor of PFKFB3 with IC50 of 137 nM, inhibits glycolysis, induces apoptosis and autophagy.

PFK-158 reduces glucose uptake, ATP production, lactate release, and induces apoptosis and autophagy in cancer cells.

PFK-158 has synergistic anti-proliferative effects in vitro when combined with Cisplatin in C13 and HeyA8MDR cells.

PFK-158 shows a dose-dependent downregulation of p62/SQSTM1 and upregulation of LC3BII, two markers of autophagy induction, in both C13 and HeyA8MDR cells.

PFK-158 combined with CBPt treatment leads to significantly enhanced antitumor activity in a gynecologic cancer mouse model.

PFK-158 is more potent than 3PO with improved PK properties.

Physicochemical Properties

M.Wt	328.288
Formula	C18H11F3N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-

References

1. Sucheta Telang, et al. Cancer Metab. 2014; 2(Suppl 1): P14.

PFK-158 (PFK 158;PFK158)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.