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Chemical Structure : PFKL activator NA-11
Catalog No.: PC-38283Not For Human Use, Lab Use Only.
PFKL activator NA-11 is a small-molecule, selective PFKL activator, inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL).
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PFKL activator NA-11 is a small-molecule, selective PFKL activator, inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL).
NA-11 binds to the AMP/ADP allosteric activation site, inhibits NOX2-dependent NETosis induced by PMA with IC50 of 4 nM.
NA-11 does not inhibit NETosis by directly modifying the enzymatic activity of NAMPT.
NA-11 relieved inhibition of PFKL by ATP (3.1 mM) with EC50 of 14 nM in in vitro kinase assays.
Neutrophils treated with NA-11 had reduced NOX2-dependent outputs, including neutrophil cell death (NETosis) and tissue damage.
| M.Wt | 401.466 | |
| Formula | C24H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Neri Amara, et al. Cell. 2021 Aug 19;184(17):4480-4494.e15.
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