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PG3d

Chemical Structure : PG3d

CAS No.: 1438463-77-4

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PG3d (Caspase-6 inhibitor PG3d)

Catalog No.: PC-73049Not For Human Use, Lab Use Only.

PG3d (Caspase-6 inhibitor PG3d) is a cell-active, allosteric and irreversible, non-competitive Caspase-6 inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PG3d (Caspase-6 inhibitor PG3d) is a cell-active, allosteric and irreversible, non-competitive Caspase-6 inhibitor.
    PG3d preferentially inhibits the cleavage of protein over peptide substrates both with purified proteins and in live cells.
    PG3d prevents the C6 (Caspase-6)-HTT interaction and prevents mHTT1-586 mediated activation of procaspase-6.
    PG3d specifically inhibits the cleavage of protein, but not peptide substrates of Caspase-6.

    Physicochemical Properties

    M.Wt 303.317
    Formula C19H13NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-Benzyl-4-hydroxy-2-(phenylethynyl)-6H-1,3-oxazin-6-one

    References

    1. Ehrnhoefer DE, et al. Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6.

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