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Chemical Structure : PHA-680632
CAS No.: 398493-79-3
Catalog No.: PC-42420Not For Human Use, Lab Use Only.
PHA-680632 is a potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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PHA-680632 is a potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively.
PHA-680632 exhibits at least 30- to 200-fold selectivity against a panel of 22 kinases compared with Aurora A.
PHA-680632 has potent antiproliferative activity in a wide range of cancer cell types (IC50=0.06-7.15 uM).
PHA-680632 shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses.
| M.Wt | 501.6232 | |
| Formula | C28H35N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]- |
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1. Soncini C, et al. Clin Cancer Res. 2006 Jul 1;12(13):4080-9.
2. Tao Y, et al. Br J Cancer. 2007 Dec 17;97(12):1664-72.
3. Ratushny V, et al. Oncogene. 2012 Mar 8;31(10):1217-27.
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