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Chemical Structure : PHA-793887
CAS No.: 718630-59-2
Catalog No.: PC-42777Not For Human Use, Lab Use Only.
PHA-793887 is a potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively, >6-fold less potency on CDK1/4/6.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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PHA-793887 is a potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively, >6-fold less potency on CDK1/4/6.
PHA-793887 shows good efficacy in the human ovarian A2780, colon HCT-116 and pancreatic BX-PC3 carcinoma xenograft models.
PHA-793887 is suitable for intravenous dosing.
| M.Wt | 361.4818 | |
| Formula | C19H31N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Butanamide, 3-methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]- |
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1. Brasca MG, et al. Bioorg Med Chem. 2010 Mar 1;18(5):1844-53.
2. Locatelli G, et al. Mol Cancer Ther. 2010 May;9(5):1265-73.
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