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PHA-793887

Chemical Structure : PHA-793887

CAS No.: 718630-59-2

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PHA-793887 (PHA793887)

Catalog No.: PC-42777Not For Human Use, Lab Use Only.

PHA-793887 is a potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively, >6-fold less potency on CDK1/4/6.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PHA-793887 is a potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively, >6-fold less potency on CDK1/4/6.
PHA-793887 shows good efficacy in the human ovarian A2780, colon HCT-116 and pancreatic BX-PC3 carcinoma xenograft models.
PHA-793887 is suitable for intravenous dosing.

Physicochemical Properties

M.Wt 361.4818
Formula C19H31N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Butanamide, 3-methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]-

References

1. Brasca MG, et al. Bioorg Med Chem. 2010 Mar 1;18(5):1844-53.

2. Locatelli G, et al. Mol Cancer Ther. 2010 May;9(5):1265-73.

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