PHD2 inhibitor BNS

Chemical Structure : PHD2 inhibitor BNS

Catalog No.: PC-22620Not For Human Use, Lab Use Only.

PHD2 inhibitor BNS is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.3 uM, 0.11 uM, 3.4 uM and 0.25 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively.

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Biological Activity

PHD2 inhibitor BNS is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.3 uM, 0.11 uM, 3.4 uM and 0.25 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively.

Physicochemical Properties

M.Wt	420.45
Formula	C18H16N2O6S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3-Dihydro-3-hydroxy-2-[[2-[(2-naphthalenylmethyl)sulfonyl]acetyl]imino]-4-thiazoleacetic acid

References

1. Thomas P Corner, et al. Chem Sci. 2023 Oct 27;14(43):12098-12120.

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