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PI5P4Kγ inhibitor 40

Chemical Structure : PI5P4Kγ inhibitor 40

CAS No.: 2766854-03-7

PI5P4Kγ inhibitor 40

Catalog No.: PC-38270Not For Human Use, Lab Use Only.

PI5P4Kγ inhibitor 40 is a selective, non-ATP-competitive, allosteric inhibitor of PI5P4Kγ with pIC50 of 6.2, does not inhibit PI5P4Kα/β with pIC50<4.6.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PI5P4Kγ inhibitor 40 is a selective, non-ATP-competitive, allosteric inhibitor of PI5P4Kγ with pIC50 of 6.2, does not inhibit PI5P4Kα/β with pIC50<4.6.

    Physicochemical Properties

    M.Wt 357.461
    Formula C22H23N5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(2-isopropylphenyl)-5-methyl-N-(pyridin-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

    References

    1. Helen K Boffey, et al. J Med Chem. 2022 Feb 11. doi: 10.1021/acs.jmedchem.1c01819.

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