PIKfyve inhibitor 40

Chemical Structure : PIKfyve inhibitor 40

Catalog No.: PC-23927Not For Human Use, Lab Use Only.

PIKfyve inhibitor 40 is a potent, selective, second-generation inhibitor of PIKfyve with enzyme IC50 of 0.6 nM, and 0.35 nM in NanoBRET assays.

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Biological Activity

PIKfyve inhibitor 40 is a potent, selective, second-generation inhibitor of PIKfyve with enzyme IC50 of 0.6 nM, and 0.35 nM in NanoBRET assays.
PIKfyve inhibitor 40 demonstrates weak binding (IC50 > 1700 nM) to all kinases except for PIP4K2C (IC50 = 200 nM), has a > 500-fold in-cell selectivity for PIKfyve versus the remainder of kinases in the 240-member NanoBRET panel.

Physicochemical Properties

M.Wt	294.38
Formula	C16H14N4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-(3-(Methylthio)prop-1-yn-1-yl)-1H-indol-3-yl)pyrimidin-2-amine

References

1. Min SM, et al. J Med Chem. 2025 Jan 22. doi: 10.1021/acs.jmedchem.4c02531.

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