Chemical Structure : PIM-447
CAS No.:
1210608-43-7
PIM-447
(LGH-447;PIM447;LGH447)
Catalog No. : PC-45605Not For Human Use, Lab Use Only.
PIM-447 (LGH-447) is a highly potent and selective inhibitor of pan-Pim with IC50s of 6/18/9 pM for Pim/1/2/3 respectively.
Packing Price Stock Quantity 1 mg $128 In stock 0 1 2 3 4 5 2 mg $178 In stock 0 1 2 3 4 5 5 mg $278 In stock 0 1 2 3 4 5 10 mg Get quote 0 1 2 3 4 5 25 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4560501
Biological Activity
PIM-447 (LGH-447) is a highly potent and selective inhibitor of pan-Pim with IC50s of 6/18/9 pM for Pim/1/2/3 respectively.
Physicochemical Properties
M.Wt
440.4608
Formula
C24H23F3N4O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-
References
1. Burger MT, et al. J Med Chem.
2. Paíno T, et al. Clin Cancer Res.
3. Peters TL, et al. Oncotarget.
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