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Chemical Structure : PIM-447
CAS No.: 1210608-43-7
Catalog No.: PC-45605Not For Human Use, Lab Use Only.
PIM-447 (LGH-447) is a highly potent and selective inhibitor of pan-Pim with IC50s of 6/18/9 pM for Pim/1/2/3 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $128 | In stock | |
| 2 mg | $178 | In stock | |
| 5 mg | $278 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote |
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PIM-447 (LGH-447) is a highly potent and selective inhibitor of pan-Pim with IC50s of 6/18/9 pM for Pim/1/2/3 respectively.
PIM-447 (LGH-447) induces apoptosis by a decrease in phospho-Bad Ser112 and c-Myc levels and the inhibition of mTORC1 pathway.
PIM-447 (LGH-447) significantly reduces the tumor burden and prevents tumor-associated bone loss in a murine model of human myeloma.
| M.Wt | 440.4608 | |
| Formula | C24H23F3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro- |
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1. Burger MT, et al. J Med Chem. 2015 Nov 12;58(21):8373-86.
2. Paíno T, et al. Clin Cancer Res. 2017 Jan 1;23(1):225-238.
3. Peters TL, et al. Oncotarget. 2016 Sep 27;7(39):63362-63373.
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