PIP-199 | RMI-MM2 inhibitor | Probechem Biochemicals

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Chemical Structure : PIP-199

PIP-199 (PIP 199)

Catalog No.: PC-21028Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PIP-199 is a small-molecule inhibitor of the Fanconi anemia complementation group M-RecQ-mediated genome instability protein (FANCM-RMI) protein-protein interaction, inhibits RMI core complex with Kd of 3.4 uM.
PIP-199 exhibits selective inhibition of the RMI core complex/MM2 complex formation with IC50 of 36 uM.
PIP-199 similarly phenocopies FANCM depletion.

Physicochemical Properties

M.Wt	456.55
Formula	C27H28N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1CCN(C(C2=C(C3=CC=CC=C3)N(O)C4=C2C=CC=C4)C5=NC=CC=C5)CC1)OCC

References

1. Andrew F Voter, et al. J Biomol Screen. 2016 Jul;21(6):626-33.

2. Xinyi Wu, et al. J Med Chem. 2023 Aug 9. doi: 10.1021/acs.jmedchem.3c00674.

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PIP-199 (PIP 199)

Biological Activity

Physicochemical Properties

References

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