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PKCθ inhibitor 22

Chemical Structure : PKCθ inhibitor 22

CAS No.: 1160501-81-4

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PKCθ inhibitor 22 (PKCθ-IN-22)

Catalog No.: PC-73053Not For Human Use, Lab Use Only.

PKCθ inhibitor 22 is a potent, selective, orally bioavailable inhibitor of Protein Kinase Cθ (PKCθ) with IC50 of 6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PKCθ inhibitor 22 is a potent, selective, orally bioavailable inhibitor of Protein Kinase Cθ (PKCθ) with IC50 of 6 nM.
    PKCθ inhibitor 22 inhibits IL-2 release from PBMCs following stimulation with anti-CD3/CD28 (IC50=0.19 uM).
    PKCθ inhibitor 22 also inhibits the release of IL-17 from CD3/CD28 stimulated Th-17 cells with an IC50 of 1 uM.
    PKCθ inhibitor 22 demonstrated a reduction of symptoms in a mouse model of multiple sclerosis.

    Physicochemical Properties

    M.Wt 348.329
    Formula C17H15F3N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

    References

    1. Collier PN, et al. ACS Med Chem Lett. 2019 Jun 27;10(8):1134-1139.

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