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Chemical Structure : PKF118-310
CAS No.: 84-82-2
Catalog No.: PC-61786Not For Human Use, Lab Use Only.
Toxoflavin (PKF118-310) is a novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | Get quote |
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Toxoflavin (PKF118-310) is a novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity.
Toxoflavin (PKF118-310) produces in vitro antitumor activity in a panel of cancer cell.
Toxoflavin (PKF118-310) reduces β-catenin nuclear localization and induces apoptosis, and inhibits expression of Tcf4 responsive genes.
| M.Wt | 193.16 | |
| Formula | C7H7N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,6-dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione |
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1. Lu W, et al. Eur J Pharmacol. 2009 Jan 5;602(1):8-14.
2. Martinez-Font E, et al. Mol Cancer Ther. 2017 Jun;16(6):1166-1176.
3. Franci G, et al. Epigenetics. 2017 Mar 4;12(3):198-205.
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