PLpro inhibitor compound 7

Chemical Structure : PLpro inhibitor compound 7

Catalog No.: PC-26441Not For Human Use, Lab Use Only.

PLpro inhibitor compound 7 is a potent, selective and covalent SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 94 nM and EC50 of 1.1 uM in SARS-CoV-2-infected Vero E6 cells

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Biological Activity

PLpro inhibitor compound 7 is a potent, selective and covalent SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 94 nM and EC50 of 1.1 uM in SARS-CoV-2-infected Vero E6 cells

Physicochemical Properties

M.Wt	488.54
Formula	C27H28N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (R,E)-4-(2-(3-(4-amino-2-((1-(naphthalen-1-yl)ethyl)carbamoyl)phenyl)propanoyl)hydrazineyl)-4-oxobut-2-enoate

References

1. Sanders BC, et al. Nat Commun. 2023 Mar 28;14(1):1733.

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