Chemical Structure : PM289
CAS No.:
1949725-88-5
PM289
(PM-289)
Catalog No.: PC-27323Not For Human Use, Lab Use Only.
PM289 is a high affinity, selective Cannabinoid 2 Receptor (CB2R) agonist with Ki of 92.6 nM (hCB2), >300-fold selectivity over hCB1 receptors.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PM289 is a high affinity, selective Cannabinoid 2 Receptor (CB2R) agonist with Ki of 92.6 nM (hCB2), >300-fold selectivity over hCB1 receptors.
PM289 attenuates NFκB activation in response to TNFα.
PM289 reduces forskolin-stimulated cAMP accumulation in HEK293-CB2R cells in a CB2-dependent manner.
PM289 attenuates TNFα-induced upregulation of ICAM-1.
PM289 reduces barrier disruption in brain microvascular endothelial cells.
PM289 increases wound repair in brain endothelial cells.
PM289 attenuates NFκB activation in response to TNFα.
PM289 modulates morphine-induced antinociceptive effect and withdrawal syndrome in rat model of knee osteoarthritis-associated pain, including both sexes.
Physicochemical Properties
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M.Wt
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384.56
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Formula
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C24H36N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-(1,1-Dimethylheptyl)-2-ethyl-2,4-dihydro-9-methoxy-4,4-dimethylchromeno[4,3-c]pyrazole
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References
1. Bullock TA, et al. NeuroImmune Pharm Ther. 2023 Oct 16;2(4):387-400.
2. Garcia MM, et al. Neuropharmacology. 2026 Jul 1;299:111090.
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