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PNU-112455A

Chemical Structure : PNU-112455A

CAS No.: 21886-12-4

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PNU-112455A (PNU112455A)

Catalog No.: PC-62677Not For Human Use, Lab Use Only.

PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively, shows no activity against c-Met, IGR-1R, and ERK2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively, shows no activity against c-Met, IGR-1R, and ERK2.

Physicochemical Properties

M.Wt 301.749
Formula C10H12ClN5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N4-(6-aminopyrimidin-4-yl)-sulfanilamide hydrochloride

References

1. Clare PM, et al. J Biol Chem. 2001 Dec 21;276(51):48292-9.

2. Monaco EA 3rd, et al. Biochem Pharmacol. 2004 May 15;67(10):1947-64.

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