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Chemical Structure : PNU 96415E
Catalog No.: PC-60613Not For Human Use, Lab Use Only.
A potential antipsychotic agent that binds selectively to D4 and 5-HT2A receptors with Ki of 3.0 and 5.8 nM, respectively.
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A potential antipsychotic agent that binds selectively to D4 and 5-HT2A receptors with Ki of 3.0 and 5.8 nM, respectively; has relatively lower affinities for D1, D2, D3, 5-HT1A and α2 receptors (Ki=200-400 nM), and no affitnity for muscarinic receptors; inhibits exploratory locomotor activity in mice and rats, and antagonizes d-amphetamine-induced locomotor stimulation in rats; also selectively inhibits GBM neural stem cells (GNS) growth and promotes differentiation of normal neural stem cells.
| M.Wt | 413.358 | |
| Formula | C21H27Cl2FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tang AH, et al. J Pharmacol Exp Ther. 1997 Apr;281(1):440-7.
2. Dolma S, et al. Cancer Cell. 2016 Jun 13;29(6):859-873.
3. Goudie AJ, et al. Behav Pharmacol. 1998 Dec;9(8):699-710.
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