Chemical Structure : PNU 96415E
CAS No.:
170856-41-4
PNU 96415E
(PNU-96415E;PNU96415E )
Catalog No.: PC-60613Not For Human Use, Lab Use Only.
A potential antipsychotic agent that binds selectively to D4 and 5-HT2A receptors with Ki of 3.0 and 5.8 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A potential antipsychotic agent that binds selectively to D4 and 5-HT2A receptors with Ki of 3.0 and 5.8 nM, respectively; has relatively lower affinities for D1, D2, D3, 5-HT1A and α2 receptors (Ki=200-400 nM), and no affitnity for muscarinic receptors; inhibits exploratory locomotor activity in mice and rats, and antagonizes d-amphetamine-induced locomotor stimulation in rats; also selectively inhibits GBM neural stem cells (GNS) growth and promotes differentiation of normal neural stem cells.
Physicochemical Properties
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M.Wt
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413.358
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Formula
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C21H27Cl2FN2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(±)-1-(4-Fluorophenyl)-4-[2-(isochroman-1-yl)ethyl]piperazine dihydrochloride
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References
1. Tang AH, et al. J Pharmacol Exp Ther. 1997 Apr;281(1):440-7.
2. Dolma S, et al. Cancer Cell. 2016 Jun 13;29(6):859-873.
3. Goudie AJ, et al. Behav Pharmacol. 1998 Dec;9(8):699-710.
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