POL2438 |CAS:790223-00-6 Probechem Biochemicals

Chemical Structure : POL2438

POL2438 (POL 2438;POL-2438)

Catalog No.: PC-61291Not For Human Use, Lab Use Only.

A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.9 nM in Ca2+ flux assay.

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Biological Activity

A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.9 nM in Ca2+ flux assay; potently inhibits the T-tropic R4 viruses entry.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclo[3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)- L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)- L-ornithyl-L-cysteinyl-L-arginylglycyl-D-prolyl- L-arginyl-L-arginyl], cyclic (2?1)-disulfide

References

1. DeMarco SJ, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8396-404.

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POL2438 (POL 2438;POL-2438)

Biological Activity

Physicochemical Properties

References

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