Chemical Structure : POL3026
CAS No.:
918660-21-6
POL3026
(POL 3026;POL-3026 )
Catalog No.: PC-61290Not For Human Use, Lab Use Only.
A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay; shows excellent plasma stability, high selectivity for CXCR4, favorable pharmacokinetic properties in vivo, has the potential to become a therapeutic compound for application in the treatment of HIV infections (as an entry inhibitor), cancer (for angiogenesis suppression and inhibition of metastasis), inflammation, and in stem cell transplant therapy.
HIV Infection
Discontinued
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Cyclo[3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-L-glutaminyl-
L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-
L-ornithyl-L-cysteinyl-L-arginylglycyl-D-prolyl-
L-arginyl-L-arginyl], cyclic (2?1)-disulfide
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References
1. DeMarco SJ, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8396-404.
2. Moncunill G, et al. Mol Pharmacol. 2008 Apr;73(4):1264-73.
3. Lesniak WG, et al. Mol Pharm. 2015 Mar 2;12(3):941-53.
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