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POL5551

Chemical Structure : POL5551

CAS No.:

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POL5551 (POL-5551;POL 5551)

Catalog No.: PC-61289Not For Human Use, Lab Use Only.

POL5551 is a peptidic, potent and highly selective CXCR4 antagonist with IC50 of 1.7 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

POL5551 is a peptidic, potent and highly selective CXCR4 antagonist with IC50 of 1.7 nM.
POL5551 displays about 200-fold lower than Plerixafor (IC50=400-600 nM), and mobilizes hematopoietic stem and progenitor cells (HSPCs) with greater efficiency than Plerixafor, does not induce major morphological changes in the BM of mice.
POL5551 reduces the migration of breast cancer cells in vitro, and reduces metastasis and prolongs survival in mice.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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