Chemical Structure : PP 242
CAS No.:
1092351-67-1
PP 242
(Torkinib, PP242, PP-242)
Catalog No. : PC-42608Not For Human Use, Lab Use Only.
Torkinib (PP242) is a potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4260801
Biological Activity
Torkinib (PP242) is a potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2 , respectively.
Physicochemical Properties
M.Wt
308.3378
Formula
C16H16N6O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1H-Indol-5-ol, 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-
References
1. Janes MR, et al. Nat Med.
2. Feldman ME, et al. PLoS Biol.
3. Hoang B, et al. J Biol Chem.
4. Hsieh AC, et al. Cancer Cell.
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