PPARγ pSer273-IN-10

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Chemical Structure : PPARγ pSer273-IN-10

Catalog No.: PC-72950Not For Human Use, Lab Use Only.

PPARγ pSer273-IN-10 is a specific, in vivo-active small molecule inhibitor of CDK5-mediated Ser273 phosphorylation of PPARγ without classical PPARγ agonism.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PPARγ pSer273-IN-10 is a specific, in vivo-active small molecule inhibitor of CDK5-mediated Ser273 phosphorylation of PPARγ without classical PPARγ agonism.
PPARγ pSer273-IN-10 is a potent PPARγ binder and in vitro inhibitor of the CDK5-mediated phosphorylation of PPARγ Ser273 and displays negligible PPARγ agonism in a reporter gene assay.
PPARγ pSer273-IN-10 demonstrated an improvement in insulin sensitivity in the ob/ob diabetic mouse model in 7 day treatment in vivo testing.

Physicochemical Properties

M.Wt	441.264
Formula	C22H14Cl2N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3,4-dichlorobenzyl)-4-oxo-6-phenoxy-3,4-dihydrophthalazine-1-carboxylic acid

References

1. Gavin O'Mahony, et al. ACS Medicinal Chemistry Letters, March 11, 2022.

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