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PPTN

Chemical Structure : PPTN

CAS No.: 1160271-30-6

PPTN

Catalog No.: PC-22102Not For Human Use, Lab Use Only.

PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.
PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors at 1 uM.
PPTN inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Physicochemical Properties

M.Wt 475.51
Formula C29H24F3NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid

References

1. Yu J, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00168.

2. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68.

3. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9.

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