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PPTN

Chemical Structure : PPTN

CAS No.: 1160271-30-6

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PPTN

Catalog No.: PC-35050Not For Human Use, Lab Use Only.

PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.
    PPTN  exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors at 1 uM.
    PPTN  inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

    Physicochemical Properties

    M.Wt 475.511
    Formula C29H24F3NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-(piperidin-4-yl)-phenyl)-7-(4-(trifluoromethyl)-phenyl)-2-naphthoic acid

    References

    1. Yu J, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00168.

    2. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68.

    3. Kiselev E, et al. ACS Chem Biol. 2014 Dec 19;9(12):2833-42.

    4. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9.

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