PPTN trifluoroacetate salt |CAS:2187367-09-3 Probechem Biochemicals

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Chemical Structure : PPTN trifluoroacetate salt

PPTN trifluoroacetate salt

Catalog No.: PC-35051Not For Human Use, Lab Use Only.

PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.
PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors at 1 uM.
PPTN inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Physicochemical Properties

M.Wt	589.534
Formula	C31H25F6NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(piperidin-4-yl)-phenyl)-7-(4-(trifluoromethyl)-phenyl)-2-naphthoic acid trifluoroacetate salt

References

1. Yu J, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00168.

2. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68.

3. Kiselev E, et al. ACS Chem Biol. 2014 Dec 19;9(12):2833-42.

4. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9.

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