PRGL493 (PRGL 493) is a potent selective inhibitor of Acyl-CoA synthetase 4 (ACSL4).
PRGL493 inhibited the proliferation of highly aggressive breast and prostate cancer cells with IC50 of 23 uM and 27 uM, respectively.
PRGL493 blocked cell proliferation and tumor growth in both breast and prostate cellular and animal models and sensitized tumor cells to chemotherapeutic and hormonal treatment.
PGRL493 inhibited de novo steroid synthesis in testis and adrenal cells, in a mouse model and in prostate tumor cells.
