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PRI-724

Chemical Structure : PRI-724

CAS No.: 1422253-38-0

PRI-724 (Foscenvivint;OP-724;PRI724;OP724)

Catalog No.: PC-70120Not For Human Use, Lab Use Only.

PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.
PRI-724 (OP-724) binds specifically to the co-activator CBP, but not to p300.
PRI-724 (OP-724) selectively induces apoptosis in colon carcinoma cells but not in normal colon cells, and exhibits antitumor activity in the mouse xenograft models of colon cancer.

Physicochemical Properties

M.Wt 658.65
Formula C33H35N6O7P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate

References

1. Sasaki T, et al. Transl Respir Med. 2014 Sep 11;2:8.

2. Zhang X, et al. Am J Cancer Res. 2015 Jul 15;5(8):2344-60.

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