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PRL-295

Chemical Structure : PRL-295

CAS No.: 2377770-85-7

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PRL-295 (PRL295)

Catalog No.: PC-72862Not For Human Use, Lab Use Only.

PRL-295 is a small molecule Keap1-Nrf2 protein-protein interaction inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PRL-295 is a small molecule Keap1-Nrf2 protein-protein interaction inhibitor.
    PRL-295 binds to Keap1 in the cellular environment, disrupting its interaction with Nrf2, which leads to enhanced gene expression of the classical Nrf2 target NQO1 in cells and in vivo in the mouse liver.
    PRL-295 increases the thermostability of Keap1 in cell lysates and in live cells.
    PRL-295 decreased the levels of plasma alanine aminotransferase and aspartate aminotransferase upon acetaminophen-induced hepatic injury.

    Physicochemical Properties

    M.Wt 639.617
    Formula C27H24F3N3O8S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-((4-methoxy-N-(2,2,2-trifluoroethyl)phenyl)sulfonamido)isoquinolin-1-yl)-N-((4-methoxyphenyl)sulfonyl)glycine

    References

    1. Dayalan Naidu S, et al. iScience. 2021 Dec 27;25(1):103703.

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