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Chemical Structure : PRN371
Catalog No.: PC-62557Not For Human Use, Lab Use Only.
PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2.
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PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2.
PRN371 effectively inhibits IL-2 induces JAK1/3-STAT5 phosphorylation in PBMCs with IC50 of 99 nM, effectively blocks JAK3-mediated signaling in JAK3-driven cancer cells.
PRN371 effectively inhibits the growth of NKTL cells via suppressing the JAK3-STAT pathway, and exhibits a more durable inhibition on JAK3 compared to tofacitinib in vitro.
PRN371 significantly inhibits tumor growth in NKTL xenograft model harboring JAK3 activating mutation.
| M.Wt | 363.421 | |
| Formula | C20H21N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nairismägi M-, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0004-x.
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