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PRT-060318

Chemical Structure : PRT-060318

CAS No.: 1194961-19-7

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PRT-060318 (PRT318)

Catalog No.: PC-43303Not For Human Use, Lab Use Only.

PRT-060318 is a potent and selective Syk inhibitor with IC50 of 4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PRT-060318 is a potent and selective Syk inhibitor with IC50 of 4 nM.
PRT-060318 shows selectivity in a broad panel of kinase enzyme assays.
PRT-060318 completely inhibits Heparin-induced thrombocytopenia (HIT) immune complex-induced aggregation of both human and transgenic HIT mouse platelet.
 

Physicochemical Properties

M.Wt 340.4228
Formula C18H24N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 5.6 mg/mL
Chemical Name/SMILES

5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(3-methylphenyl)amino]-

References

1. Reilly MP, et al. Blood. 2011 Feb 17;117(7):2241-6.

2. Hoellenriegel J, et al. Leukemia. 2012 Jul;26(7):1576-83.

3. Andre P, et al. Blood. 2011 Nov 3;118(18):5000-10.

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