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PSB-0739

Chemical Structure : PSB-0739

CAS No.: 1052087-90-7

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PSB-0739 (PSB0739)

Catalog No.: PC-21206Not For Human Use, Lab Use Only.

PSB-0739 is a high potent, non-nucleotide-derived competitive antagonist of platelet P2Y12 receptor with Ki of 24.9 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PSB-0739 is a high potent, non-nucleotide-derived competitive antagonist of platelet P2Y12 receptor with Ki of 24.9 nM.
PSB-0739 is a potent competitive non-nucleotide antagonist at the human P2Y12 receptor with a pA2 value of 9.8.
PSB-0739 inhibits ADP-evoked Ca2+ responses with an EC50 of 5.4±1.8 μM and causes a rightward parallel shift in the ADP concentration–response curve in THP-1 cells.

Physicochemical Properties

M.Wt 609.53
Formula C26H17N3Na2O8S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Amino-9,10-dihydro-9,10-dioxo-4-[[4-(phenylamino)-3-sulfophenyl]amino]-2-anthracenesulfonic acid sodium salt

References

1. Baqi Y, et al. J Med Chem. 2009 Jun 25;52(12):3784-93.

2. Hoffmann K, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):648-55.

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