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PSB-22034

Chemical Structure : PSB-22034

CAS No.: 2768131-22-0

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PSB-22034 (PSB22034, PSB 22034)

Catalog No.: PC-21318Not For Human Use, Lab Use Only.

PSB-22034 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 11.2 nM/32.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PSB-22034 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 11.2 nM/32.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.
PSB-22034 shows high selectivity over the other MRGPRX subtypes, MRGPRX1, -2, and -3.
PSB-22034 is a promising tool compound for exploring the potential of MRGPRX4 as a future drug target.

Physicochemical Properties

M.Wt 460.43
Formula C21H25N4O6P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(8-(3-Methoxyphenethyl)-2,6-dioxo-1-(prop-2-yn-1-yl)-1,2,6,7-tetrahydro-3H-purin-3-yl)butyl)phosphonic Acid

References

1. Marx D, et al. J Med Chem. 2023 Nov 15. doi: 10.1021/acs.jmedchem.3c01013.

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