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Chemical Structure : PSI-697
CAS No.: 851546-61-7
Catalog No.: PC-22341Not For Human Use, Lab Use Only.
PSI-697 is a potent, selective and orally bioavailable P-selectin antagonist with biacore IC50 of 150 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PSI-697 is a potent, selective and orally bioavailable P-selectin antagonist with biacore IC50 of 150 uM.
PSI-697 dose dependently inhibits the binding of human P-selectin to human P-selectin glycoprotein ligand-1, inhibiting 50% of binding at 50 to 125 microM.
PSI-697 shows oral efficacy in mouse and rat models of atherogenesis and vascular injury.
PSI-697 (50 mg/kg p.o.) significantly reduced the number of rolling leukocytes by 39% (P < 0.05) versus vehicle control in surgical inflammation rat model.
PSI-697 (100 mg/kg p.o.) reduced thrombus weight by 18% (P < 0.05) relative to vehicle, without prolonging bleeding time, in rat venous thrombosis model.
| M.Wt | 367.83 | |
| Formula | C21H18ClNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid |
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1. Kaila N, et al. J Med Chem. 2007 Jan 11;50(1):40-64.
2. Bedard PW, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):497-506.
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