PSNCBAM-1 is an allosteric antagonist of CB1 receptor with IC50 of 22.5 nM in Ca2+ assays, inhibits [3H]CP55,940 binding with EC50 of 167 nM. PSNCBAM-1 does not affect CB2 receptors.
PSNCBAM-1 blocked the effects induced by agonists such as CP55,940, WIN55212-2, anandamide (AEA) or 2-arachidonoyl glycerol (2-AG) in CB1 receptor yeast reporter assays.
PSNCBAM-1 decreased food intake and body weight in an acute rat feeding model.
