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Chemical Structure : PSNCBAM-1
CAS No.: 877202-74-9
Catalog No.: PC-72731Not For Human Use, Lab Use Only.
PSNCBAM-1 is an allosteric antagonist of CB1 receptor with IC50 of 22.5 nM in Ca2+ assays, inhibits [3H]CP55,940 binding with EC50 of 167 nM.
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| 10 mg | $178 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $428 | In stock | |
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PSNCBAM-1 is an allosteric antagonist of CB1 receptor with IC50 of 22.5 nM in Ca2+ assays, inhibits [3H]CP55,940 binding with EC50 of 167 nM. PSNCBAM-1 does not affect CB2 receptors.
PSNCBAM-1 blocked the effects induced by agonists such as CP55,940, WIN55212-2, anandamide (AEA) or 2-arachidonoyl glycerol (2-AG) in CB1 receptor yeast reporter assays.
PSNCBAM-1 decreased food intake and body weight in an acute rat feeding model.
| M.Wt | 392.887 | |
| Formula | C22H21ClN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 nM in DMSO |
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| Chemical Name/SMILES |
1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea |
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1. Horswill JG, Br J Pharmacol. 2007 Nov;152(5):805-14.
2. Wang X, et al. Mol Pharmacol. 2011 Apr;79(4):758-67.
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