Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PSNCBAM-1
CAS No.: 877202-74-9
Catalog No.: PC-72731Not For Human Use, Lab Use Only.
PSNCBAM-1 is an allosteric antagonist of CB1 receptor with IC50 of 22.5 nM in Ca2+ assays, inhibits [3H]CP55,940 binding with EC50 of 167 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $258 | In stock | |
| 100 mg | $658 | In stock | |
| 250 mg | $958 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PSNCBAM-1 is an allosteric antagonist of CB1 receptor with IC50 of 22.5 nM in Ca2+ assays, inhibits [3H]CP55,940 binding with EC50 of 167 nM. PSNCBAM-1 does not affect CB2 receptors.
PSNCBAM-1 blocked the effects induced by agonists such as CP55,940, WIN55212-2, anandamide (AEA) or 2-arachidonoyl glycerol (2-AG) in CB1 receptor yeast reporter assays.
PSNCBAM-1 decreased food intake and body weight in an acute rat feeding model.
| M.Wt | 392.887 | |
| Formula | C22H21ClN4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 nM in DMSO |
|
| Chemical Name/SMILES |
1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea |
|
1. Horswill JG, Br J Pharmacol. 2007 Nov;152(5):805-14.
2. Wang X, et al. Mol Pharmacol. 2011 Apr;79(4):758-67.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
