PSTC | Nrf2 activator | Probechem Biochemicals

Chemical Structure : PSTC

PSTC (Nrf2 activator PSTC)

Catalog No.: PC-60630Not For Human Use, Lab Use Only.

PSTC is a potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity).

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Biological Activity

PSTC is a potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity).
PSTC induces Nrf2 nuclear translocation, Nrf2-regulated gene expression, and downstream signaling events, including induction of NAD(P)H:NQO1 enzyme activity and heme oxygenase-1 protein expression, in an Nrf2-dependent manner.
PSTC does not inhibit IL-1β-induced NF-κB translocation or insulin-induced S6 phosphorylation in human cells.
PSTC restores oxidant (tert-butyl hydroperoxide)-induced glutathione depletion in vitro and in vivo models of pulmonary oxidative stress.

Physicochemical Properties

M.Wt	355.287
Formula	C15H8F3NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one

References

1. Yonchuk JG, et al. J Pharmacol Exp Ther. 2017 Aug 8. pii: jpet.117.241794.

PSTC (Nrf2 activator PSTC)

Biological Activity

Physicochemical Properties

References

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