PT-91 | GPR27 agonist | Probechem Biochemicals

Chemical Structure : PT-91

PT-91 (GPR27 agonist PT-91)

Catalog No.: PC-21541Not For Human Use, Lab Use Only.

PT91 is a small-molecule GPR27 (SREB1) agonist with pEC50 of 6.15 (human GPR27) in β-arrestin 2 recruitment-based firefly luciferase complementation assay, Emax=100%.

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Biological Activity

PT91 is a small-molecule GPR27 (SREB1) agonist with pEC50 of 6.15 (human GPR27) in β-arrestin 2 recruitment-based firefly luciferase complementation assay, Emax=100%.
PT91 displays no activity against the adrenoceptor β2 (β2AR).
PT91 does not significantly influence the levels of cAMP through GPR27.
PT91 displays high metabolic stability and brain exposure in mice.

Physicochemical Properties

M.Wt	450.43
Formula	C21H17F3N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methoxy-N-(4-(N-phenylsulfamoyl)phenyl)-4-(trifluoromethyl)benzamide

References

1. Thanigaimalai Pillaiyar, et al. Journal of Medicinal Chemistry, 2023.

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PT-91 (GPR27 agonist PT-91)

Biological Activity

Physicochemical Properties

References

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