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Chemical Structure : PTP1B-IN-2
CAS No.: 1919853-46-5
Catalog No.: PC-20596Not For Human Use, Lab Use Only.
PTP1B-IN-2 (compound P6) is a potent, selective potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 50 nM, >40-fold selectivity over SHP-2 and LAR, >15-fold selectivity over the highly homologous TCPTP.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $658 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PTP1B-IN-2 (compound P6) is a potent, selective potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 50 nM, >40-fold selectivity over SHP-2 and LAR, >15-fold selectivity over the highly homologous TCPTP.
PTP1B-IN-2 (15 and 30 uM) greatly enhances insulin-mediated IRβ phosphorylation, significantly increases insulin-stimulated glucose uptake in L6 myotube.
| M.Wt | 680.79 | |
| Formula | C34H36N2O9S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=C(OC)C1=CC(N(CC2=CC=C(N(CC(OC)=O)S(=O)(C)=O)C=C2)S(=O)(CC3=CC=CC=C3)=O)=CC=C1OCC4=CC=C(C)C=C4 |
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1. Peihong Liu, et al. Eur J Med Chem. 2016 Aug 8;118:27-33.
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