Catalog No.: PC-20596Not For Human Use, Lab Use Only.
PTP1B-IN-2 (compound P6) is a potent, selective potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 50 nM, >40-fold selectivity over SHP-2 and LAR, >15-fold selectivity over the highly homologous TCPTP.
PTP1B-IN-2 (compound P6) is a potent, selective potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 50 nM, >40-fold selectivity over SHP-2 and LAR, >15-fold selectivity over the highly homologous TCPTP. PTP1B-IN-2 (15 and 30 uM) greatly enhances insulin-mediated IRβ phosphorylation, significantly increases insulin-stimulated glucose uptake in L6 myotube.
