PTP1B-IN-5b |CAS:2101230-45-7 Probechem Biochemicals

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Chemical Structure : PTP1B-IN-5b

PTP1B-IN-5b

Catalog No.: PC-62844Not For Human Use, Lab Use Only.

PTP1B-IN-5b is a potent protein tyrosine phosphatase PTP1B inhibitor with IC50 of 5.25 uM.

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Biological Activity

PTP1B-IN-5b is a potent protein tyrosine phosphatase PTP1B inhibitor with IC50 of 5.25 uM.
PTP1B-IN-5b shows remarkable cytotoxic activity at 0.09 uM of IC50 against the MCF-7 cell line.
PTP1B-IN-5b also showed potential anticancer activity against MCF-7 (IC50=2.22 uM) and HepG2 (IC50=0.72 uM) cell lines as well as PTP1B inhibitory activity with IC50 of 6.37 uM.

Physicochemical Properties

M.Wt	417.479
Formula	C24H19NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-(4-(2-naphthamido)phenyl)-3-methoxythiophene-2-carboxylate

References

1. Gulipalli KC, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3558-3564.

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PTP1B-IN-5b

Biological Activity

Physicochemical Properties

References

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