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Chemical Structure : PTPN22 inhibitor NC1
Catalog No.: PC-21074Not For Human Use, Lab Use Only.
PTPN22 inhibitor NC1 is a specific, noncompetitive, allosteric PTPN22 (lymphoid-specific tyrosine phosphatase, LYP) inhibitor with Ki of 4.3 uM, effectively and specifically inhibits LYP-mediated TCR signaling in T cells.
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PTPN22 inhibitor NC1 is a specific, noncompetitive, allosteric PTPN22 (lymphoid-specific tyrosine phosphatase, LYP) inhibitor with Ki of 4.3 uM, effectively and specifically inhibits LYP-mediated TCR signaling in T cells.
PTPN22 inhibitor NC1 displays at least 1.9-fold higher selectivity against a panel of other protein phosphatases, including STEP, PTPN18, Glepp, VHR, and the Ser/Thr phosphatases PPM1A and PP1.
PTPN22 inhibitor NC1 (20 uM) significantly increased the phosphorylation levels of ERK and LCK in Jurkat T cells, shows no effect on CD3-induced LCK and ERK phosphorylation in T cells without endogenous LYP expression.
| M.Wt | 546.59 | |
| Formula | C29H26N2O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li K, et al. J Biol Chem.2019 May 24;294(21):8653-8663.
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