PUS7 inhibitor C17

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-PUS7 inhibitor C17

Chemical Structure : PUS7 inhibitor C17

Catalog No.: PC-72856Not For Human Use, Lab Use Only.

PUS7 inhibitor C17 is a small molecule inhibitor of pseudouridine synthase PUS7, preferentially targets glioblastoma stem cells (GSCs) compared to NSCs.

Packing	Price	Stock	Quantity
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PUS7 inhibitor C17 is a small molecule inhibitor of pseudouridine synthase PUS7, preferentially targets glioblastoma stem cells (GSCs) compared to NSCs.
PUS7 inhibitor C17 potently inhibits growth of multiple GSC lines (PBT003, PBT707, PBT726, and PBT111) in range 4 nM to 400 nM (IC50=92.15 nM, PBT003 GSCs).
PUS7 inhibitor C17 displays no inhibitory effect on control brain-derived normal NSCs.
PUS7 inhibitor C17 could inhibit pseudouridine modification by PUS7 and suppress GSC growth.
PUS7 inhibitor C17 suppresses tumor progression, prolong the lifespan of tumor-bearing mice.
PUS7 modifies tRNAs, reduces TYK2 translation, and downregulates a proliferation-restricting interferon-STAT1 pathway in glioblastoma.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
Shipping
Solubility
Chemical Name/SMILES

References

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com