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Chemical Structure : PVP-037.2
Catalog No.: PC-22584Not For Human Use, Lab Use Only.
PVP-037.2 is a small-molecule that induces cytokine production, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity.
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PVP-037.2 is a small-molecule that induces cytokine production and TLR7/8 agonist, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity.
ODN 20958 (TLR7 specific antagonist) completely blocks PVP-037.2-induced TNF production in human PBMCs.
PVP-037.2 acts in synergy with a squalene-based oil in water formulation to enhance cytokine induction in vitro and vaccine immunogenicity in vivo.
The type 1 immunomodulatory profile of PVP-037.2 is mediated by TLR7.
Formulation of PVP-037.2 with squalene enhanced its adjuvanticity.
PVP-037.2 demonstrates a TLR7/8-dependent immunomodulatory profile.
| M.Wt | 439.44 | |
| Formula | C23H20F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Soni D, et al. Sci Adv. 2024 Jul 5;10(27):eadg3747.
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