Chemical Structure : PVP-037.2
CAS No.:
3049666-32-9
PVP-037.2
(PVP037.2)
Catalog No.: PC-22584Not For Human Use, Lab Use Only.
PVP-037.2 is a small-molecule that induces cytokine production, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PVP-037.2 is a small-molecule that induces cytokine production and TLR7/8 agonist, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity.
ODN 20958 (TLR7 specific antagonist) completely blocks PVP-037.2-induced TNF production in human PBMCs.
PVP-037.2 acts in synergy with a squalene-based oil in water formulation to enhance cytokine induction in vitro and vaccine immunogenicity in vivo.
The type 1 immunomodulatory profile of PVP-037.2 is mediated by TLR7.
Formulation of PVP-037.2 with squalene enhanced its adjuvanticity.
PVP-037.2 demonstrates a TLR7/8-dependent immunomodulatory profile.
Physicochemical Properties
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M.Wt
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439.44
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Formula
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C23H20F3N5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(aminomethyl)-N-(2-methyl-5-(6-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl)-2-(trifluoromethyl)benzamide
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References
1. Soni D, et al. Sci Adv. 2024 Jul 5;10(27):eadg3747.
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