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Chemical Structure : PW0729
Catalog No.: PC-22470Not For Human Use, Lab Use Only.
PW0729 is a potent, selective, G protein-biased agonist of orphan GPR52 with EC50 of 47 nM in cAMP assay, Emax=143%.
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PW0729 is a potent, selective, G protein-biased agonist of orphan GPR52 with EC50 of 47 nM in cAMP assay, Emax=143%.
PW0729 shows EC50 of 110 nM in β-arrestin recruitment assay.
PW0729 is highly selective for GPR52 agonism with no significant off-target effects at other brain GPCRs.
PW0729 is also bioavailable but hs less than optimal brain permeability, requiring further optimization.
| M.Wt | 415.42 | |
| Formula | C22H20F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ryan E Murphy, et al. J Med Chem. 2024 Jun 13;67(11):9709-9730.
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