PW0729 | GPR52 agonist | Probechem Biochemicals

Chemical Structure : PW0729

PW0729 (PW-0729)

Catalog No.: PC-22470Not For Human Use, Lab Use Only.

PW0729 is a potent, selective, G protein-biased agonist of orphan GPR52 with EC50 of 47 nM in cAMP assay, Emax=143%.

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Biological Activity

PW0729 is a potent, selective, G protein-biased agonist of orphan GPR52 with EC50 of 47 nM in cAMP assay, Emax=143%.
PW0729 shows EC50 of 110 nM in β-arrestin recruitment assay.
PW0729 is highly selective for GPR52 agonism with no significant off-target effects at other brain GPCRs.
PW0729 is also bioavailable but hs less than optimal brain permeability, requiring further optimization.

Physicochemical Properties

M.Wt	415.42
Formula	C22H20F3N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-Hydroxyethyl)-3-((4-(3-(trifluoromethyl)benzyl)pyridin-2-yl)amino)benzamide

References

1. Ryan E Murphy, et al. J Med Chem. 2024 Jun 13;67(11):9709-9730.

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PW0729 (PW-0729)

Biological Activity

Physicochemical Properties

References

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