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PWZ-029

Chemical Structure : PWZ-029

CAS No.: 164025-33-6

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PWZ-029 (PWZ029)

Catalog No.: PC-62625Not For Human Use, Lab Use Only.

PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo.
    PWZ-029 successfully reverses the 0.3 mg/kg scopolamine-induced deficit in recognition memory at 2 mg/kg dose with no effect on anxiety or muscle tone.

    Physicochemical Properties

    M.Wt 291.735
    Formula C14H14ClN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

    References

    1. Savić MM, et al. Brain Res. 2008 May 7;1208:150-9.

    2. Milić M, et al. Behav Brain Res. 2013 Mar 15;241:206-13.

    3. Soto PL, et al. Neuropsychopharmacology. 2013 Oct;38(11):2315-25.

    4. Timić Stamenić T, et al. J Psychopharmacol. 2015 Sep;29(9):1013-24.

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