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Chemical Structure : PWZ-029
Catalog No.: PC-62625Not For Human Use, Lab Use Only.
PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo.
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PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo; successfully reverses the 0.3 mg/kg scopolamine-induced deficit in recognition memory at 2 mg/kg dose with no effect on anxiety or muscle tone.
| M.Wt | 291.735 | |
| Formula | C14H14ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Savić MM, et al. Brain Res. 2008 May 7;1208:150-9.
2. Milić M, et al. Behav Brain Res. 2013 Mar 15;241:206-13.
3. Soto PL, et al. Neuropsychopharmacology. 2013 Oct;38(11):2315-25.
4. Timić Stamenić T, et al. J Psychopharmacol. 2015 Sep;29(9):1013-24.
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