Chemical Structure : PX-478
CAS No.: 685898-44-6
Catalog No.: PC-42474Not For Human Use, Lab Use Only.
PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity.
PX-478 inhibits the hypoxia-induced increase in HIF-1α protein in PC-3, MCF-7, HT-29 and Panc-1 with IC50 of 3.9, 4.0, 19.4 and 10.1 nM, respectively.
PX-478 suppresses HIF-1α levels in HT-29 human colon cancer xenografts and inhibits the expression of HIF-1 target genes including VEGFR and the glucose transporter-1.
| M.Wt | 394.1215 | |
| Formula | C13H20Cl4N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, (Hydrochloride) (1:2) |
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1. Welsh S, et al. Mol Cancer Ther. 2004 Mar;3(3):233-44.
2. Jordan BF, et al. Neoplasia. 2005 May;7(5):475-85.
3. Koh MY, et al. Mol Cancer Ther. 2008 Jan;7(1):90-100.
4. Schwartz DL, et al. Mol Cancer Ther. 2009 Apr;8(4):947-58.
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