Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-PXS-4681A
PXS-4681A

Chemical Structure : PXS-4681A

CAS No.: 1478364-87-2

Add to Favorites

PXS-4681A (PXS-4681, PXS4681A)

Catalog No.: PC-61472Not For Human Use, Lab Use Only.

PXS-4681A is a potent, selective, and irreversible inhibitor of semicarbazide-sensitive amine oxidase (SSAO, VAP-1) with Ki of 37 nM, IC50 of <10 nM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PXS-4681A is a potent, selective, and irreversible inhibitor of semicarbazide-sensitive amine oxidase (SSAO, VAP-1) with Ki of 37 nM, IC50 of <10 nM.
    PXS-4681A displays 250- and 4000-fold selectivity over DAO and LOX.
    PXS-4681A attenuates neutrophil migration, TNF-α, and IL-6 levels in mouse models of lung inflammation and localized inflammation;orally activie.

    Physicochemical Properties

    M.Wt 296.741
    Formula C10H14ClFN2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-4-(2-(aminomethyl)-3-fluoroallyloxy)benzenesulfonamide hydrochloride

    References

    1. Foot JS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):365-74.

    2. Becchi S, et al. Br J Pharmacol. 2017 Jul;174(14):2302-2317.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: