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Chemical Structure : PXS-4681A
Catalog No.: PC-61472Not For Human Use, Lab Use Only.
PXS-4681A is a potent, selective, and irreversible inhibitor of semicarbazide-sensitive amine oxidase (SSAO, VAP-1) with Ki of 37 nM, IC50 of <10 nM.
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PXS-4681A is a potent, selective, and irreversible inhibitor of semicarbazide-sensitive amine oxidase (SSAO, VAP-1) with Ki of 37 nM, IC50 of <10 nM.
PXS-4681A displays 250- and 4000-fold selectivity over DAO and LOX.
PXS-4681A attenuates neutrophil migration, TNF-α, and IL-6 levels in mouse models of lung inflammation and localized inflammation;orally activie.
| M.Wt | 296.741 | |
| Formula | C10H14ClFN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Foot JS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):365-74.
2. Becchi S, et al. Br J Pharmacol. 2017 Jul;174(14):2302-2317.
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