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PXS-6302

Chemical Structure : PXS-6302

CAS No.: 2584947-54-4

PXS-6302 (PXS6302)

Catalog No.: PC-49358Not For Human Use, Lab Use Only.

PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.

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Biological Activity

PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-6302 is a more selective inhibitor than β-aminoproprionitrile (BAPN) and is also optimally designed for topical application.
Topical application of PXS-6302 (1.5% PXS-6302 oil in water cream) reduces skin fibrosis in repeat dose bleomycin-induced skin fibrosis in mice.
Topical application of PXS-6302 (1.5% PXS-6302 oil in water cream) reduces collagen deposition and crosslinking in a murine model of excision injury.
Topical application of PXS-6302 (3% PXS-6302 oil in water cream) improves scar appearance with no reduction in tissue strength in porcine models of excision and burn injury.

Physicochemical Properties

M.Wt 265.250
Formula C10H10F3NO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-3,4,4-trifluoro-4-(phenylsulfonyl)but-2-en-1-amine

References

1. Nutan Chaudhari, et al. Nat Commun. 2022 Sep 22;13(1):5555.

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