Catalog No.: PC-49358Not For Human Use, Lab Use Only.
PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-6302 is a more selective inhibitor than β-aminoproprionitrile (BAPN) and is also optimally designed for topical application.
Topical application of PXS-6302 (1.5% PXS-6302 oil in water cream) reduces skin fibrosis in repeat dose bleomycin-induced skin fibrosis in mice.
Topical application of PXS-6302 (1.5% PXS-6302 oil in water cream) reduces collagen deposition and crosslinking in a murine model of excision injury.
Topical application of PXS-6302 (3% PXS-6302 oil in water cream) improves scar appearance with no reduction in tissue strength in porcine models of excision and burn injury.
