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Chemical Structure : PYD-106
Catalog No.: PC-49064Not For Human Use, Lab Use Only.
PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator, enhances the maximal current response of GluN1/GluN2C receptors.
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PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator with EC50 of 13 uM, enhances the maximal current response of GluN1/GluN2C receptors.
PYD-106 (30 uM) does not alter responses of NMDA receptors containing GluN2A, GluN2B, and GluN2D and has no effect on AMPA and kainate receptors.
PYD-106 was effective concentration of glutamate and glycine increases the response of GluN1/GluN2C NMDA receptors in HEK-293 cells to 221% (EC50=13 uM).
PYD-106 increased opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only had modest effects on glutamate and glycine EC50.
PYD-106 selectively enhanced the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors.
| M.Wt | 432.476 | |
| Formula | C25H24N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Khatri A, et al. Mol Pharmacol. 2014 Nov;86(5):548-60.
2. Kaiser TM, et al. Mol Pharmacol. 2018 Feb;93(2):141-156.
3. Zimmerman SS, et al. J Med Chem 57:2334-2356.
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