PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator with EC50 of 13 uM, enhances the maximal current response of GluN1/GluN2C receptors.
PYD-106 (30 uM) does not alter responses of NMDA receptors containing GluN2A, GluN2B, and GluN2D and has no effect on AMPA and kainate receptors.
PYD-106 was effective concentration of glutamate and glycine increases the response of GluN1/GluN2C NMDA receptors in HEK-293 cells to 221% (EC50=13 uM).
PYD-106 increased opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only had modest effects on glutamate and glycine EC50.
PYD-106 selectively enhanced the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors.
