Catalog No.: PC-35831Not For Human Use, Lab Use Only.
PZ-2891 (PZ2891) a specific, allosteric, BBB-permeable, orally active Pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM, hPANK3) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA in biochemical assays.
PZ-2891 (PZ2891) a specific, allosteric, BBB-permeable, orally active Pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM, hPANK3) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA in biochemical assays.
PZ-2891 occupies the pantothenate pocket and engages the dimer interface to form a PANK•ATP•Mg2+•PZ-2891 complex.
PZ-2891 inhibits all 3 human and mouse pantothenate kinase isoforms (hPANK1α IC50=40.2 nM, hPANK2 IC50=0.7 nM).
PZ-2891 increases intracellular CoA in cultured cells and elevates CoA levels in mouse liver and brain, improves gain weight, locomotor activity and life span in mouse model of brain CoA deficiency.
