Chemical Structure : PZ-3022
CAS No.:
2170608-85-0
PZ-3022
(PZ3022)
Catalog No.: PC-28328Not For Human Use, Lab Use Only.
PZ-3022 is an allosteric, orally bioavailable Pantothenate kinase (PanK) activator with EC50 of 5.3 nM against PanK3, shows a lower affinity for PanK isoforms PANK1β and PANK2m with EC50 of 789 nM and 15 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PZ-3022 is an allosteric, orally bioavailable Pantothenate kinase (PanK) activator with EC50 of 5.3 nM against PanK3, shows a lower affinity for PanK isoforms PANK1β and PANK2m with EC50 of 789 nM and 15 nM respectively.
PZ-3022 renders PanK resistant to C3-CoA inhibition in vitro.
PZ-3022 (10 or 30 mg/kg) relieves CoASH sequestration in liver by increasing hepatic CoASH and C2-CoA and decreasing C3-CoA, consistent with the stimulation of TCA cycle flux.
PZ-3022 relieved hepatic CoA sequestration and elevated CoASH and C2-CoA in male propionic acidemia (PA) mice.
PZ-3022 allosterically activates PanK to counteract its inhibition by C3-CoA and normalizes the intracellular concentrations of total CoA, CoASH, and C2-CoA, and reduces C3-CoA in PA liver.
Physicochemical Properties
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M.Wt
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347.42
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Formula
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C20H21N5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-[4-[2-(4-Cyclopropylphenyl)acetyl]-1-piperazinyl]-3-pyridazinecarbonitrile
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References
1. Subramanian C, et al. Sci Transl Med. 2021 Sep 15;13(611):eabf5965.
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