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Chemical Structure : Palbociclib
CAS No.: 571190-30-2
Catalog No.: PC-45862Not For Human Use, Lab Use Only.
Palbociclib (PD0332991) is a potent and selective, orally bioavailable inhibitor of CDK4/6 with IC50 of 11 nM/16 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 250 mg | $198 | In stock | |
| 500 mg | $298 | In stock | |
| 1 g | $478 | In stock | |
| 5 g | Get quote |
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Palbociclib (PD0332991) is a potent and selective, orally bioavailable inhibitor of CDK4/6 with IC50 of 11 nM/16 nM.
Palbociclib (PD0332991) shows no inhibition for CDK2A (IC50>5 uM).
Palbociclib (PD0332991) inhibits MDA-MB453 cells with IC50 of 0.16 uM.
Palbociclib (PD0332991) shows antiproliferative effect against retinoblastoma (Rb)-positive tumor cells in vitro and reduces the phospho-Ser780/Ser795 on the Rb protein.
| M.Wt | 447.5327 | |
| Formula | C24H29N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 0.2 mg/mL (Need ultrasonic or warming) |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]- |
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1. Toogood PL, et al. J Med Chem. 2005 Apr 7;48(7):2388-406.
2. Fry DW, et al. Mol Cancer Ther. 2004 Nov;3(11):1427-38.
3. Baughn LB, et al. Cancer Res. 2006 Aug 1;66(15):7661-7.
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