Palbociclib (PD0332991) | CDK4/6 inhibitor

Chemical Structure : Palbociclib

CAS No.: 571190-30-2

Palbociclib (PD0332991, PD-0332991)

Catalog No.: PC-45862Not For Human Use, Lab Use Only.

Palbociclib (PD0332991) is a potent and selective, orally bioavailable inhibitor of CDK4/6 with IC50 of 11 nM/16 nM.

Packing	Price	Stock
50 mg	$88	In stock
100 mg	$128	In stock
250 mg	$198	In stock
500 mg	$298	In stock
1 g	$478	In stock
5 g		Get quote

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Biological Activity

Palbociclib (PD0332991) is a potent and selective, orally bioavailable inhibitor of CDK4/6 with IC50 of 11 nM/16 nM.
Palbociclib (PD0332991) shows no inhibition for CDK2A (IC50>5 uM).
Palbociclib (PD0332991) inhibits MDA-MB453 cells with IC50 of 0.16 uM.
Palbociclib (PD0332991) shows antiproliferative effect against retinoblastoma (Rb)-positive tumor cells in vitro and reduces the phospho-Ser780/Ser795 on the Rb protein.

Physicochemical Properties

M.Wt	447.5327
Formula	C24H29N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 0.2 mg/mL (Need ultrasonic or warming)
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-

References

1. Toogood PL, et al. J Med Chem. 2005 Apr 7;48(7):2388-406.

2. Fry DW, et al. Mol Cancer Ther. 2004 Nov;3(11):1427-38.

3. Baughn LB, et al. Cancer Res. 2006 Aug 1;66(15):7661-7.

Palbociclib (PD0332991, PD-0332991)

Biological Activity

Physicochemical Properties

References

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