Palbociclib (PD0332991) hydrochloride | CDK4/6 inhibitor

Chemical Structure : Palbociclib hydrochloride

CAS No.: 827022-32-2

Palbociclib hydrochloride (PD-0332991 hydrochloride, PD0332991 hydrochloride)

Catalog No.: PC-45863Not For Human Use, Lab Use Only.

Palbociclib (PD0332991) hydrochloride is a potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM.

Packing	Price	Stock
25 mg	$98	In stock
50 mg	$158	In stock
100 mg	$258	In stock
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Biological Activity

Palbociclib (PD0332991) hydrochloride is a potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM.
Palbociclib (PD0332991) shows no inhibition for CDK2A (IC50>5 uM).
Palbociclib (PD0332991) inhibits MDA-MB453 cells with IC50 of 0.16 uM.
Palbociclib (PD0332991) shows antiproliferative effect against retinoblastoma (Rb)-positive tumor cells in vitro and reduces the phospho-Ser780/Ser795 on the Rb protein; orally bioavailable.

Physicochemical Properties

M.Wt	483.9937
Formula	C24H30ClN7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 6 mg/mL (Need ultrasonic or warming)
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, hydrochloride (1:1)

References

1. Toogood PL, et al. J Med Chem. 2005 Apr 7;48(7):2388-406.

2. Fry DW, et al. Mol Cancer Ther. 2004 Nov;3(11):1427-38.

3. Baughn LB, et al. Cancer Res. 2006 Aug 1;66(15):7661-7.

Palbociclib hydrochloride (PD-0332991 hydrochloride, PD0332991 hydrochloride)

Biological Activity

Physicochemical Properties

References

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