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Pannexin-1 inhibitor 15b

Chemical Structure : Pannexin-1 inhibitor 15b

CAS No.: 2765454-32-6

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Pannexin-1 inhibitor 15b (Pannexin-1 inhibitor)

Catalog No.: PC-72399Not For Human Use, Lab Use Only.

Panx-1 blocker 15b is a large-pore channel pannexin 1 (Panx1) inhibitor with IC50 of 0.8 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Pannexin-1 inhibitor 15b is a large-pore channel pannexin 1 (Panx1) inhibitor with IC50 of 0.8 uM.
    Pannexin-1 inhibitor 15b (administered intrathecally, 1 nM) completely reverted the hypersensitivity in the mouse model of oxaliplatin-induced neuropa.

    Physicochemical Properties

    M.Wt 508.501
    Formula C25H20N2O8S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-Carboxybenzyl)-5-(N-(4-carboxybenzyl)sulfamoyl)-1Hindole-2-carboxylic acid

    References

    1. Letizia Crocetti, et al. Eur J Med Chem. 2021 Nov 5;223:113650.

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